喜歡吃甜食的人要注意了!過多糖分不只造成肥胖,還會造成壽命縮短!
















根據最新一期的國際知名權威期刊Cell reports,

報導指出除了一般民眾所知道的吃太多甜食會造成肥胖以外,

還可能造成壽命縮短,該研究人員發現果繩與人類共同擁有的基因dFOXO,

在長期使用高濃度糖份飲食的果繩比正常果繩壽命來得的短,

且該文重點是就算攝取高濃度糖分的果繩,

恢復正常飲食也無法回復正常的壽命!!

是屬於不可逆性,也就是無法修復!

所以如果你很愛吃甜食的朋友要儘早節制哦!

包括HO自己也是orz..


摘要原文如下:


Summary:


Consumption of unhealthy diets is exacerbating the burden of age-related ill health in aging populations. Such diets can program mammalian physiology to cause long-term, detrimental effects. Here, we show that, in Drosophila melanogaster, an unhealthy, high-sugar diet in early adulthood programs lifespan to curtail later-life survival despite subsequent dietary improvement. Excess dietary sugar promotes insulin-like signaling, inhibits dFOXO—the Drosophila homolog of forkhead box O (FOXO) transcription factors—and represses expression of dFOXO target genes encoding epigenetic regulators. Crucially, dfoxo is required both for transcriptional changes that mark the fly’s dietary history and for nutritional programming of lifespan by excess dietary sugar, and this mechanism is conserved in Caenorhabditis elegans. Our study implicates FOXO factors, the evolutionarily conserved determinants of animal longevity, in the mechanisms of nutritional programming of animal lifespan.